CHEK1 anticorps (pSer296)

N° du produit ABIN6989950

Cet anticorps Lapin Monoclonal détecte spécifiquement CHEK1 dans WB, IHC et IHC (p). Il présente une réactivité envers Humain.

Aperçu rapide pour CHEK1 anticorps (pSer296) (ABIN6989950)

Antigène: CHEK1 (Checkpoint Kinase 1 (CHEK1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp CHEK1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 4B6

Détail du produit anti-CHEK1 anticorps

Épitope: pSer296

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: Synthetic phospho-Peptide corresponding to residues surrounding Ser296 of human Chk1

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC()

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur CHEK1

Antigène: CHEK1 (Checkpoint Kinase 1 (CHEK1))

Autre désignation: Chk1

Sujet:

Synonyms: C85740 antibody, Cell cycle checkpoint kinase antibody, Checkpoint , S. pombe, homolog of, 1 antibody, Checkpoint kinase 1 antibody, Checkpoint kinase 1 homolog (S. pombe) antibody, CHEK 1 antibody, Chek1 antibody, Chk 1 antibody, Chk1 antibody, CHK1 checkpoint homolog (S. pombe) antibody, CHK1_HUMAN antibody, EC 2.7.11.1 antibody, rad27 antibody, Serine/threonine protein kinase Chk1 antibody, Serine/threonine-protein kinase CHK1 antibody, STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) antibody

Background: The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2011].

ID gène: 1111

UniProt: O14757

Pathways: Signalisation p53, Apoptose, Cycle Cellulaire, Réparation de l'ADN